The annual road safety enforcement 'Operation Go Slow' starts at mid-night and will run through until Tuesday.

Double demerits will be in force throughout the period for speeding, seatbelt, mobile phone and motorcycle helmet offences.

Superintendent Bob Noble said the school holidays have already started with a tragic event in Old Junee on September 28.

"We don't want anymore, anywhere, particularly across the Riverina but we can probably be assured there will be some serious accidents," Superintendent Noble said.

"We want to keep them to a minimum, so we urge people to manage their fatigue ... we don't want people to drive under the influence of alcohol or drugs - that's obviously a no-brainer, but you'd be surprised by how many people continue to do it."

Superintendent Noble said the biggest risk currently is distraction, particularly using mobile phones while driving.

"They're a pretty big risk for us and we'll continue to be very stringent of our enforcement of driver distraction over the long weekend," he said.

Minister for Regional Transport and Roads Paul Toole said speeding, driving under the influence and fatigue were the biggest killers on NSW roads.

"We need all motorists to play their part in keeping our road toll down," Mr Toole said.

"Don't take a risk that you may regret for life.

"As our clocks tick forward an hour for daylight savings, we're reminding motorists to make sure their kilometres don't tick forward too and if you're planning on watching the Roosters and the Raiders battle it out during the Grand Final, make sure you have a plan b."

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