Traffic along the highway is still being impacted after the early morning crash, which occurred around five kilometres west of Collingullie a little after 5am.

Fire and Rescue NSW Riverina zone head Superintendent Stewart Alexander said it appeared truck trailers had clipped each other while passing along the 100km/h highway.

"We were alerted ... to a crash involved two semi-trailers," he said.

"They were travelling in opposite directions and looks like they've sideswiped each other. They were carrying general freight so there was no dangerous goods (involved)."

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A spokesperson for NSW Police confirmed no one was injured in the crash and police were finished at the scene soon after 7am.

Debris from the trucks was strewn along a 300m stretch of the road, Superintendent Alexander said.

It's the latest in a string of crashes involving heavy vehicles in the region, and less than a week after young man Braidy North-Flanagan was killed when his ute collided with a grocery-laden truck on the same highway east of Wagga.

Another man had escaped serious injury after his sedan and a B-double were involved in a collision near Borambola three days prior.

Two men also died when the truck they were travelling in west of Young collided with a freight train near Bribbaree later that day.

The crash comes the day after the member for Riverina, Michael McCormack, announced the Sturt Highway will receive a number of upgrades aimed at preventing road crashes under a statewide funding blitz.

The road remains affected as clean-up continues and stop/slow traffic conditions are in place.

Motorists are urged to exercise caution, check signange and allow for extra travel time.

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