Ole Gunnar Solskjaer's men were riding the crest of a wave after Sunday's FA Cup win against Liverpool, only to be brought crashing down to earth on a night when many expected them to go back top of the league.

Ex-Manchester City youth prospect Kean Bryan gave the visitors a shock lead that former Blades defender Harry Maguire cancelled out, only for Burke's heavily deflected strike to seal the visitors a shock 2-1 win at Old Trafford.

Even in such an unpredictable season, few could have foreseen this result.

The Blades had just five points to show from their first 19 games - the worst haul in Premier League history - and had not beaten the Red Devils since 1993, with their previous Old Trafford victory coming in 1973.

"We're surprised," Solskjaer said after United's first loss in the league since November 1.

"We have been the most consistent team the last few months but it just hit us today."

Kean got Sheffield off the mark from a corner as Billy Sharp's push on David De Gea went unpunished midway through a first half in which Anthony Martial saw an equaliser ruled out.

The ineffective hosts eventually clawed one back through Maguire's header from a corner, but Solskjaer's comeback kings faltered in embarrassing fashion.

Sheffield United capitalised on some atrocious defending and Burke saw his effort rifle in off Axel Tuanzebe, sealing just a fourth win of the season in all competitions for his side.

"We have had to play near-perfect from our point of view against world-class players and a team that is flying high," Wilder said.

"All season we have had pretty tight games and not come out the right side. We took our big moments."

Thomas Tuchel's Chelsea career fell prey to a frustrating launch as the Blues laboured to a galling goalless English Premier League draw with Wolverhampton.

Former Paris St Germain boss Tuchel replaced Frank Lampard on Tuesday, with the Blues board hailing the 47-year-old as one of Europe's top coaches.

Chelsea struggled for fluency in a tepid first half as many of the issues that beset ex-boss Lampard surfaced again at Stamford Bridge though.

And despite dominating possession and territory throughout, Chelsea were forced to settle for a draw - which extends their paltry league return to just two wins in nine matches.

"I was very happy with the intensity, the attitude, energy and quality of my team," Tuchel said.

"We were well organised, had a lot of ball recoveries in the last third, never lacked intensity.

"Unfortunately we couldn't score.

"If we take care of our performance like this, the results will come."

In other games, Burnley twice came from behind to claim a 3-2 victory over Aston Villa in an entertaining encounter at Turf Moor.

Fulham earned their first point in three games against fellow relegation strugglers Brighton in a cagey goalless draw at the Amex Stadium.

And Everton playmaker James Rodriguez's moment of quality was cancelled out by an error from goalkeeper Jordan Pickford which allowed Leicester to leave Goodison Park with a 1-1 draw.

Australian Associated Press