Police confirmed a man, 78, and his wife, 75, were turning out of the service station near Tumbarumba Road when they collided with a semi-trailer heading east on the highway.

Emergency services were called to the accident about 4.20pm on Sunday, and both occupants of the car were freed from the wreckage by rescue crews.

They were taken to Wagga Base Hospital but died a short time later. The truck driver was uninjured, but underwent mandatory blood and urine testing.

Riverina Police District Commander Superintendent Bob Noble said the incident was a horrific accident.

"This is a particularly tragic incident and terrible news for the family and friends of the two victims, and also for the truck driver," he said.

This year alone, 14 people were killed in 12 fatal crashes in the Riverina, with three of those in the Wagga LGA.

Superintendent Noble said that at this stage of the investigation, there is "nothing to suggest the driver of the truck has committed an offence".

"Obviously, it still needs to be fully and comprehensibly investigated, but it seems to be a tragic accident that has taken place," he said.

"The truck driver is physically unharmed, but one can only imagine his psychological and emotional state under the circumstances aren't great, it's a terrible thing to find yourself caught up in and even worse for the family of the two victims."

Concerns about the safety of the intersection of Tumbarumba Road and the Sturt Highway have been raised following the crash.

One Facebook user commented saying it was an "accident waiting to happen" on what they called a "horrendous stretch of road".

Superintendent Noble said there was always a risk present at high-speed intersections.

"Any intersection or any place where people rejoin a highway is inherently dangerous, particularly where the speed limit is 100km/h or more," he said.

Ladysmith Tourist Railway treasurer Wally Bell frequents the intersection and said speed was the biggest issue.

"They've only recently done up the intersection there onto the highway and I've found it good," he said.

"Turning out of that servo there is another story though, it's dangerous and needs its own turning lane both into and out of the driveway.

"It should be 80km/h on that part though. I've come out of it before onto the highway and you have to gun it out just to make sure no one is racing up behind you."