Operations Tortoise, which runs until 11.59pm on Monday, will see police targeting speeding, mobile phone, seatbelt and motorcycle helmet offences.

Wagga's Superintendent Bob Noble said police would be enforcing road rules, but also the new restrictions around coronavirus and social isolation.

"Clearly at this time, we are discouraging people from non-essential travel. In fact, it's against the law to travel for a non-essential purpose," he said.

"If you're out and about on the roads, expect to see a very, very high visibility of police. They will be enforcing traffic legislation, they will be enforcing the COVID-19 ministerial directions.

"If you transgress on any of those boundaries, expect to be proceeded against.

"We do expect lower volumes of traffic on the road, but there will be a lot of RBT and there will be a lot of random drug testing and you're driving around and you're drinking alcohol, you can expect to be apprehended for that too."

Superintendent Noble also echoed the pleas of regional health officials for people who are showing symptoms of coronavirus to get tested.

According to NSW Police's Traffic and Highway Patrol Command, these rules on travel do not prohibit people from going to the supermarket and pharmacy, going to and from work if they cannot work from home, going to medical appointments, or leaving for some brief exercise in their own neighbourhood.

Traffic and highway patrol commander, Assistant Commissioner Michael Corboy, said there have been 88 fatalities on NSW roads so far this year, despite a recent reduction in traffic because of the new coronavirus restrictions.

"Obey the road rules and stay home unless you need to leave - it's all we ask," he said.

Bernard Carlon, executive director of the Centre for Road Safety, also urged road users not be complacent, despite the lower numbers of people on the roads.

"Despite the smaller number of vehicles travelling we are still seeing deaths on NSW roads most days and the road toll continues to rise," he said.

"It only takes one person to make an error that leads to a crash so we need everyone who is on the roads to stick to the speed limit, put the phone down, obey all of the rules and take care."