Police expect to make further arrests after uncovering drugs, cash and cars in several raids across Wagga on Tuesday.
Four people were charged over the discoveries in Kooringal, North Wagga and Mount Austin homes as specialist squad officers cracked down on the region's drug supply network.
Police seized a range of drugs, more than $10,000 in cash and two vehicles believed to be the proceeds of crime.
Two men and a woman, all aged in their 20s, were arrested at a Kooringal residence, while a fourth woman was arrested in North Wagga.
All four were taken to Wagga police station and charged over their alleged involvement in supplying MDMA, amphetamines and cocaine across the Riverina.
Wagga Police Inspector Peter McLay said the investigation had been running for several months.
"Police allege one of the young men arrested was the principal offender, meaning he was providing information and instructions to other parties involved," he said.
"Police will also allege these persons were involved in mid-level supply of prohibited drugs, but we are not foolish enough to think we have solved the drug problem in Wagga completely."
Nathan Jack Job, 20, of Horsley Street, Wagga, faces a number of charges, including two each of supplying a commercial quantity of a prohibited drug and supplying an indictable quantity of a prohibited drug.
He is also accused of dealing with proceeds of crime, knowingly directing activities of a criminal group and possessing a prohibited weapon.
Courtney Hinnenberg, 22, of Horsley Street, Wagga, has been charged with two counts each of supplying an indictable quantity of a prohibited drug, and one count each of supplying a commercial quantity of a prohibited drug, supplying a small quantity of a prohibited drug and participating in a criminal group.
Hayden Benjamin Stirling, 24, of Malaya Dr Wagga, is accused of participating in a criminal group, as well as facing two charges each of knowingly taking part in the supply of a prohibited drug and supplying an indictable amount of a prohibited drug.
The Kooringal trio did not apply for bail when they appeared in Wagga Local Court on Wednesday via videolink.
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They were formerly refused bail to reappear March 25, while the woman arrested in North Wagga will appear before Wagga Local Court on April 8.
None of the accused who appeared in court have entered pleas.
Inspector McLay said the investigation had been ongoing since late 2019.
"Investigations are ongoing as police do expect to make further arrests in the coming days," he said.