Emergency services were called to Federation Way at Daysdale about 1.15pm on Thursday after the two-truck head-on smash.

A grain truck driven by a Bacchus Marsh man, 35, collided with another truck.

The Bacchus Marsh man was critically injured and was airlifted to hospital, where he remained yesterday.

The man's partner and mother attended the Royal Melbourne Hospital on Thursday to be by his side.

His boss also attended the hospital and said the man was badly injured, with a hospital spokesman confirming he was in a serious condition.

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The man who died in the crash, believed to have been aged in his 30s, has not been formally identified.

Inspector Owen Hill said emergency services were confronted by an horrific scene.

The late man's truck split open the Bacchus Marsh driver's loaded grain truck, and landed upside down off the road.

"It is very horrific," Inspector Hill said of the incident, which involved police, paramedics, firefighters and Volunteer Rescue Association members.

"Tragically a male has lost his life, and there's another male in critical condition in hospital."

The clean-up of the site continues.

Inspector Hill said it was too early to determine the cause of the crash, with witnesses still sought.

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