Ahead of the government reintroducing the pandemic leave payments, Professor Paul Kelly has urged eligible Australians to get a third or fourth COVID vaccine, ahead of the predicted peak of the third Omicron wave.

Prof Kelly said the latest rise in cases was set to place additional pressure on hospitals.

"Due to the number of cases, we may also see a rise in the number of people dying with COVID-19, particularly among those who are at higher risk of severe disease," he said.

"We cannot stop this wave of infections, but we can slow the spread and protect the vulnerable. We have done this before and we can do it again."

The chief medical officer has also urged employers to review health and safety risks in light of the increase in infections, as well as allowing employees to work from home if possible.

Health Minister Mark Butler said the third Omicron wave was concerning.

"There were 300,000 cases or thereabouts reported over the last seven days, and I think (the chief medical officer) and I are pretty confident that the real number is likely to be double that," he told reporters in Canberra.

"The other difference obviously between the situation we confront today and in January is that hospitals are also grappling with flu and a range of other respiratory illnesses and the usual surge in hospital activity that we see during winter."

Since the eligibility widened for a fourth vaccine dose, more than 560,000 have been administered in the first week of the expanded rollout, with most being between 50 and 65-years-old.

That's compared with 180,000 doses of a second booster the week before.

However, Mr Butler wanted a greater take up of a third dose, with just 50,000 first boosters administered in the past week.

It comes as pandemic isolation payments for eligible workers will resume from Wednesday until September 30.

However, Government Services Minister Bill Shorten said employees would have to show they were not able to financially cover the impact of being off work in order to be eligible for the $750 payment.

"If you have sick leave, you have to use your sick leave first but I stress, not your holiday leave," Mr Shorten told the Seven Network's Sunrise program on Tuesday.

"Also, if you have more than $10,000 in the bank ... so it's not a means test but if you've got liquid assets, then you are not eligible."

More than 50,500 new cases and 75 deaths have been recorded nationwide on Tuesday.

There are more than 348,000 active coronavirus cases Australia-wide, with more than 5200 patients in hospital care.

LATEST 24-HOUR COVID-19 DATA:

NSW: 13,554 cases, 26 deaths, 2205 in hospital with 60 in ICU

Victoria: 12,201 cases, 25 deaths, 897 in hospital with 34 in ICU

Northern Territory: 671 cases, no deaths, 63 in hospital with one in ICU

Queensland: 9992, 18 deaths, 983 in hospital with 24 in ICU

ACT: 1221 cases, no deaths, 170 in hospital with six in ICU

WA: 6815 cases, three deaths, 455 in hospital with 20 in ICU

SA: 4172 cases, three deaths, 282 in hospital with 11 in ICU

Tasmania: 1642 cases, no deaths, 184 in hospital, two in ICU.

Australian Associated Press