NSW Police said the incident occurred just after 8.30pm, with a man later charged and due to appear in court on Sunday.

"Officers attached to Murray River Police District were conducting proactive patrols of the Albury area when they observed two men involved in a physical altercation on Dean Street," police said in a statement.

"As the two officers separated the men, a male senior constable was taken to the ground, before he was approached by a third unknown man and allegedly kicked in the face and knocked unconscious.

"All three men fled the scene on foot."

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The male senior constable was taken to Albury hospital in a serious condition with facial fractures and a head injury.

Officers established a crime scene and began to search the surrounding area.

"A short time later, officers arrested the two men involved in the physical altercation - aged 22 and 20 - in separate locations nearby," police said.

"Following inquiries, a 20-year-old Wodonga man was arrested at Albury Police Station about 10.15pm.

"The 20-year-old Wodonga man was charged with cause grievous bodily harm to person with intent to resist arrest.

"He was refused bail to appear before Wagga Wagga Bail Court today (Sunday).

"The older man - who was allegedly involved in the physical altercation - was charged with affray and assault occasioning actual bodily harm.

"He was granted conditional bail to appear before Albury Local Court on Monday, November 1, 2021.

"The 20-year-old Albury man remains in police custody and inquiries continue."

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