Police are investigating whether a truck driver flung through the windshield of his vehicle at Holbrook was wearing a seatbelt.
An off-duty paramedic and nurse initially assisted the 23-year-old driver in Monday's crash.
His B-double rolled on the Hume Highway, and his arm became stuck underneath the cabin in the median strip.
Inspector Scott Trewhella said despite initial concerns, the injuries were not life threatening.
The man was flown to hospital in Canberra and has undergone treatment as police try to determine the cause.
"In any investigation we do consider all factors, whether that's a case of restraints such as seatbelts, driver fatigue, weather playing a factor," he said.
"We will look into all of those factors and try to see what's actually caused this incident."
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Police will also speak to the driver about the crash, which occurred about 11.45am.
The driver does not live in the Border region and it was unclear where he was travelling to.
Despite suffering serious injuries, Inspector Trewhella said the man was quite lucky.
"Any collision of that nature involving a heavy vehicle on a major highway has got the potential to be fatal, particularly when someone is ejected," he said.
"That is a massive concern."
Anyone who witnessed the crash is urged to contact Albury police or Crime Stoppers.
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