Agriculture minister Adam Marshall says hundreds of farmers around the state have registered for free grain treatment to combat the mice plague, ahead of the government's treatment sites becoming operational.
Regional areas like Dubbo and Mudgee are among 20 that will have treatment sites set up, with the government still awaiting Australian Pesticides and Veterinary Medicines Authority approval to use and distribute bromadiolone.
Mr Marshall said, on Sunday, the government will continue working with the APVMA to meet any environmental requirements, with more than 400 farmers already registering their interest and more than 10,000 litres of the poison secured.
"So much rests on the APVMA approval now, but we haven't been sitting on our hands while waiting for it," Mr Marshall said.
"We've secured more than 10,000 litres of bromadiolone already, announced and established 20 distribution points across rural NSW and have our qualified staff ready to go as soon as we get the green light from the APVMA.
"This is all in response to pleas from industry, hundreds of whom have now formally made an expression of interest to the NSW Government.
"I've been on the ground, I live in the bush and I speak to farmers every day and many are asking for bromadiolone to help fight these vermin and this early enthusiasm shows that."
Mr Marshall said once the government receives approval, if it does, the poison will become a perimeter-bailing tool for farmers to surround their crops, potentially as part of a 'multi-layered defence' against the rampant rodents.
"Landholders will be able to surround their crops with bromadiolone-treated grain, which when used in combination with zinc phosphide to kill off mice already in paddock, will give farmers a multi-layered defence," Mr Marshall said.
"We'll work with the Commonwealth's APVMA and, once we get the green light, the NSW Government will roll out 20 grain treatment sites in the most affected rural areas in the State so that farmers can get their grain treated free of charge."
Mr Marshall said farmers could continue to register for grain treatment online at www.lls.nsw.gov.au/mice or by calling their nearest Local Land Services office.
"This plague is unprecedented. There's no blueprint, nor no silver bullet, but we're arming our farmers with free grain treatment and more to help fight the plague," Mr Marshall said.
"Our sites will be ready to go; we just need approval to use bromadiolone as farmers were able to the last time we faced a mouse plague."