Emergency services rushed to the scene of a two-vehicle crash on the Hume Highway, two kilometres south of Holbrook, at about 5.30am on Saturday morning.

A Transport Management Centre spokesperson said diversions were put in place while first responders worked to free a trapped person.

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A NSW Ambulance spokesperson said they sent four crews, and a Toll Rescue Helicopter was dispatched but called off in the end.

"We had two people taken to Albury Base Hospital," they said.

"Two males in their 30s were in a two-vehicle accident. One person had lower leg injuries."

After four hours, the Hume Highway was open in both lanes once the clean up and vehicle salvage had been completed.

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