CSIRO technical officer Steve Henry said most of the Riverina was reporting higher than usual numbers of mice because of increased rain and bountiful food.

"Really what happens is mice are everywhere all the time and what happens is when conditions are favourable for them to breed they breed really rapidly where they already were," he said.

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Riverina grain growers will next Friday attend online crisis talks to address a mouse infestation that has razed crops in Western NSW.

"Up around Warren and Trangie, farmers are losing crops out there, so you'd call that a plague. They're literally eating all the summer crop as it's developing," Mr Henry said.

"As far as I know and the people I've spoken to near Wagga, it's not at that point yet. But if conditions remain favourable you could end up in that situation."

Flick Pest Control technician Jamie Thompson said there were already "big numbers" of mice in Wagga this summer.

He said the population had "gone through the roof" in the Riverina, with numbers doubling over the last two months in Leeton, Griffith and Hillston.

"If we're lucky enough, we won't get heaps of numbers here [in Wagga]. I don't know. I can't predict. You'd be silly to predict it because you just don't know what's coming," he said.

"They're just nasty little critters. But, they're only doing what they've got to do. They're like us, they want to survive."

He recalled Wagga's infamous mouse plague of more than a decade ago, which was prompted by swarms of locusts and saw residents resort to taping up crevices in their homes.

"We're not at plague here yet. I think the numbers are really starting to be scary out in Leeton and Griffith," he said.