Emergency services have closed the Hume Highway's northbound lanes past Gundagai following a two-car traffic incident on Sunday afternoon.
NSW Livetraffic stated that the lanes have been closed "at the Dog on the Tucker Box due to a car crash".
An Ambulance Service of NSW spokesman said a total of two cars and eight people had been involved.
"One car was carrying three people - two adults and one child - have received minor injuries and the sort of bumps and bruises you would expect from a car accident and they were showing signs of shock," he said.
"They will be taken to Wagga Base Hospital to be checked out.
"The second car had five occupants, three adults and two children, but they were able to get out of the car and did not have any injuries."
Five ambulances are attending the incident, with two on scene and three en-route as of 3.50pm on Sunday.
The first call to emergency services was at 2.59pm on Sunday and heavy traffic conditions have built up at the scene.
"Local diversion in place. Exercise caution and allow extra travel time," the NSW government traffic monitoring service stated.
Transport for NSW and emergency services are attending the scene.
The new incident came about an hour after NSW Police announced they had charged a 31-year-old Gundagai man with dangerous driving offences following a fatal collision on the Hume Highway on Saturday.
That incident, which took place near Tumblong, took the life of a 60-year-old Albury man and left a 45-year-old Albury woman in Wagga Base Hospital.