A Queensland man died on Thursday night after the vehicle he was driving collided with a B-double, flipped and burst into flames.

The 63-year-old was behind the wheel of a Mazda ute, towing a Morris Minor van on a trailer, when it made contact with the truck at Sweetwater Creek Bridge at Mullengandra just after 8.20pm.

The ute flipped, landing onto its roof and caught fire. The man died at the scene.

A rescue helicopter was called in to airlift the truck driver, a 46-year-old, following treatment at the crash site.

He has been taken to Canberra Hospital in a serious but stable condition, having suffered head and back injuries in the collision.

Murray River Police District officers were still at the scene investigating the crash on Friday morning and the northbound lanes of the highway are expected to remain closed for much of Friday.

Recovery crews were working to get the truck's trailer, which was carrying lettuces and cauliflowers, out of the creek on Friday morning.

Read more:

Northbound travelers are advised to allow an extra 30 minutes of travel time to their journey, with diversions in place.

Motorists have been directed to use the Olympic Highway to Wagga and then the Sturt Highway to rejoin the Hume.

Reduced speed limits are also in place.

Thirteen hours earlier, a man was killed and four others injured when the car they were travelling in left the road and hit a tree at Mullengandra.

A man travelling in the front passenger seat died at the scene, while two more were taken to hospital by ambulance and a fourth was airlifted from the scene. The driver was taken to Albury Base Hospital in a critical condition.

Anyone with information relating to the crash is urge to contact Crime Stoppers by calling 1800 333 000 or using the online reporting page.

While you're with us, did you know that you can now receive updates straight to your inbox each day at 6am from the Daily Advertiser? To make sure you're up to date with all the Wagga news, sign up here.